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Fitness benefits in fluoroquinolone-resistant Salmonella Typhi in the absence of antimicrobial pressure

Abstract:

Fluoroquinolones (FQ) are the recommended antimicrobial treatment for typhoid, a severe systemic infection caused by the bacterium Salmonella enterica serovar Typhi. FQ-resistance mutations in S. Typhi have become common, hindering treatment and control efforts. Using in vitro competition experiments, we assayed the fitness of eleven isogenic S. Typhi strains with resistance mutations in the FQ target genes, gyrA and parC. In the absence of antimicrobial pressure, 6 out of 11 mutants carried ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/eLife.01229.001

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Publisher:
eLife Sciences Publications
Journal:
eLife More from this journal
Volume:
2013
Issue:
2
Article number:
e01229
Publication date:
2013-12-10
Acceptance date:
2013-10-22
DOI:
EISSN:
2050-084X
Language:
English
Keywords:
UUID:
uuid:1e6caaf8-7875-4a29-a2a4-8f6a1551da1f
Local pid:
pubs:444661
Source identifiers:
444661
Deposit date:
2014-01-30

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