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Poly ADP-ribose polymerase-1: an international molecule of mystery.

Abstract:

Poly(ADP-ribose) polymerase-1 (PARP-1) is one of the most abundant proteins within mammalian cells. First described more than 45 years ago, PARP-1 has been the subject of many studies and was shown to be involved in multiple aspects of cellular metabolism. Despite many interesting studies that implicate PARP-1 in transcription, chromatin remodelling, apoptosis, DNA repair and several neurological disorders, its precise role is still unclear. This review will discuss the role of PARP-1 in DNA ...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Journal:
DNA repair
Volume:
7
Issue:
7
Pages:
1077-1086
Publication date:
2008-07-01
DOI:
EISSN:
1568-7856
ISSN:
1568-7864
Source identifiers:
130906
Language:
English
Keywords:
Pubs id:
pubs:130906
UUID:
uuid:1e6c933a-edc5-4cae-b96f-90cae045c8b7
Local pid:
pubs:130906
Deposit date:
2012-12-19

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