Journal article
A specific DNA-nanoprobe for tracking the activities of human apurinic/apyrimidinic endonuclease 1 in living cells
- Abstract:
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Human apurinic/apyrimidinic endonuclease/redox effector factor 1 (APE1) is an essential DNA repair protein. Herein, we demonstrate that avidin-oriented abasic site-containing DNA strands (AP-DNA) on the surface of silica coated magnetic nanoparticles (SiMNP) can selectively respond to APE1 while resist the digestion by other nucleases. Mechanism studies have revealed that avidin may serve as an organizer protein and recruit APE1 to the DNA substrates on the nanoparticles via strong and specif...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.9MB)
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- Publisher copy:
- 10.1093/nar/gkw1205
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Authors
Funding
+ National Natural Science Foundation of China
More from this funder
Grant:
81571130100,21575008
21375004
Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Nucleic Acids Research Journal website
- Volume:
- 45
- Issue:
- 6
- Article number:
- e45
- Publication date:
- 2017-04-07
- Acceptance date:
- 2016-11-19
- DOI:
- EISSN:
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1362-4962
- ISSN:
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0305-1048
- Source identifiers:
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721465
Item Description
- Pubs id:
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pubs:721465
- UUID:
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uuid:1e66a096-f559-4a07-894b-51aada836c3c
- Local pid:
- pubs:721465
- Deposit date:
- 2017-08-18
Terms of use
- Copyright holder:
- Zhai et al
- Copyright date:
- 2017
- Notes:
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Copyright © 2016 The Authors. Published by Oxford University Press on behalf of Nucleic Acids Research.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
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