Journal article icon

Journal article

A specific DNA-nanoprobe for tracking the activities of human apurinic/apyrimidinic endonuclease 1 in living cells

Abstract:

Human apurinic/apyrimidinic endonuclease/redox effector factor 1 (APE1) is an essential DNA repair protein. Herein, we demonstrate that avidin-oriented abasic site-containing DNA strands (AP-DNA) on the surface of silica coated magnetic nanoparticles (SiMNP) can selectively respond to APE1 while resist the digestion by other nucleases. Mechanism studies have revealed that avidin may serve as an organizer protein and recruit APE1 to the DNA substrates on the nanoparticles via strong and specif...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1093/nar/gkw1205

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
More from this funder
Name:
Beijing Natural Science Foundation
Grant:
2152014
More from this funder
Name:
National Natural Science Foundation of China
Grant:
81571130100,21575008
21375004
Publisher:
Oxford University Press
Journal:
Nucleic Acids Research More from this journal
Volume:
45
Issue:
6
Article number:
e45
Publication date:
2017-04-07
Acceptance date:
2016-11-19
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Pubs id:
pubs:721465
UUID:
uuid:1e66a096-f559-4a07-894b-51aada836c3c
Local pid:
pubs:721465
Source identifiers:
721465
Deposit date:
2017-08-18

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP