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A specific DNA-nanoprobe for tracking the activities of human apurinic/apyrimidinic endonuclease 1 in living cells

Abstract:

Human apurinic/apyrimidinic endonuclease/redox effector factor 1 (APE1) is an essential DNA repair protein. Herein, we demonstrate that avidin-oriented abasic site-containing DNA strands (AP-DNA) on the surface of silica coated magnetic nanoparticles (SiMNP) can selectively respond to APE1 while resist the digestion by other nucleases. Mechanism studies have revealed that avidin may serve as an organizer protein and recruit APE1 to the DNA substrates on the nanoparticles via strong and specif...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/nar/gkw1205

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Department:
Oxford, MSD, NDM, Target Discovery Institute
Role:
Author
Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic Acids Research Journal website
Volume:
45
Issue:
6
Pages:
Article: e45
Publication date:
2017-04-07
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Pubs id:
pubs:721465
URN:
uri:1e66a096-f559-4a07-894b-51aada836c3c
UUID:
uuid:1e66a096-f559-4a07-894b-51aada836c3c
Local pid:
pubs:721465
Paper number:
6

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