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A virus-like particle-based vaccine selectively targeting soluble TNF-alpha protects from arthritis without inducing reactivation of latent tuberculosis.

Abstract:

Neutralization of the proinflammatory cytokine TNF-alpha by mAbs or soluble receptors represents an effective treatment for chronic inflammatory disorders such as rheumatoid arthritis, psoriasis, or Crohn's disease. In this study, we describe a novel active immunization approach against TNF-alpha, which results in the induction of high titers of therapeutically active autoantibodies. Immunization of mice with virus-like particles of the bacteriophage Qbeta covalently linked to either the enti...

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Publication status:
Published

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Journal:
Journal of Immunology
Volume:
178
Issue:
11
Pages:
7450-7457
Publication date:
2007-06-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Source identifiers:
469695

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