Journal article
A virus-like particle-based vaccine selectively targeting soluble TNF-alpha protects from arthritis without inducing reactivation of latent tuberculosis.
- Abstract:
-
Neutralization of the proinflammatory cytokine TNF-alpha by mAbs or soluble receptors represents an effective treatment for chronic inflammatory disorders such as rheumatoid arthritis, psoriasis, or Crohn's disease. In this study, we describe a novel active immunization approach against TNF-alpha, which results in the induction of high titers of therapeutically active autoantibodies. Immunization of mice with virus-like particles of the bacteriophage Qbeta covalently linked to either the enti...
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- Publication status:
- Published
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- Publisher copy:
- 10.4049/jimmunol.178.11.7450
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Authors
Bibliographic Details
- Journal:
- Journal of Immunology
- Volume:
- 178
- Issue:
- 11
- Pages:
- 7450-7457
- Publication date:
- 2007-06-01
- DOI:
- EISSN:
-
1550-6606
- ISSN:
-
0022-1767
- Source identifiers:
-
469695
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:469695
- UUID:
-
uuid:1e5e11aa-abd0-4f41-993b-d66edbdc8cce
- Local pid:
- pubs:469695
- Deposit date:
- 2014-06-18
Terms of use
- Copyright date:
- 2007
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