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Journal article

Valacyclovir for herpes simplex encephalitis.

Abstract:
The recommended treatment for herpes simplex encephalitis (HSE) remains intravenous acyclovir. In resource-poor countries, however, intravenous formulations are usually unavailable or unaffordable. We report the penetration of acyclovir into the cerebrospinal fluid (CSF) in patients with HSE, treated with the oral prodrug valacyclovir at 1,000 mg three times daily. The oral therapy achieved adequate acyclovir concentrations in the CSF and may be an acceptable early treatment for suspected HSE in resource-limited settings.
Publication status:
Published

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Publisher copy:
10.1128/aac.01023-10

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Role:
Author
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Journal:
Antimicrobial agents and chemotherapy
Volume:
55
Issue:
7
Pages:
3624-3626
Publication date:
2011-07-05
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
URN:
uuid:1e59adf5-9dd6-4feb-9d02-2424b493e937
Source identifiers:
140893
Local pid:
pubs:140893

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