Journal article
Type I IFN protects cancer cells from CD8+ T cell-mediated cytotoxicity after radiation
- Abstract:
-
Treatment of tumors with ionizing radiation stimulates an antitumor immune response partly dependent on induction of IFNs. These IFNs directly enhance dendritic cell and CD8+ T cell activity. Here we show that resistance to an effective antitumor immune response is also a result of IFN signaling in a different cellular compartment of the tumor, the cancer cells themselves. We abolished type I IFN signaling in cancer cells by genetic elimination of its receptor, IFNAR1. Pronounced immune respo...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1172/JCI127458
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Authors
Funding
Bibliographic Details
- Publisher:
- American Society for Clinical Investigation Publisher's website
- Journal:
- Journal of Clinical Investigation Journal website
- Volume:
- 129
- Issue:
- 10
- Pages:
- 4224-4238
- Publication date:
- 2019-10-01
- Acceptance date:
- 2019-07-03
- DOI:
- EISSN:
-
1558-8238
- ISSN:
-
0021-9738
- Pmid:
-
31483286
- Pubs id:
-
1049655
- Local pid:
- pubs:1049655
Item Description
- Language:
- English
- Keywords:
- Format:
Terms of use
- Copyright holder:
- Chen et al.
- Copyright date:
- 2019
- Rights statement:
- © 2019 Chen, et al. This is an open access article published under the terms of the Creative Commons Attribution 4.0 International License.
- License:
- CC Attribution (CC BY)
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