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Type I IFN protects cancer cells from CD8+ T cell-mediated cytotoxicity after radiation

Abstract:

Treatment of tumors with ionizing radiation stimulates an antitumor immune response partly dependent on induction of IFNs. These IFNs directly enhance dendritic cell and CD8+ T cell activity. Here we show that resistance to an effective antitumor immune response is also a result of IFN signaling in a different cellular compartment of the tumor, the cancer cells themselves. We abolished type I IFN signaling in cancer cells by genetic elimination of its receptor, IFNAR1. Pronounced immune respo...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1172/JCI127458

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
ORCID:
0000-0002-8674-702X
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
ORCID:
0000-0001-5973-0049
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
More from this funder
Name:
Cancer Research UK
Grant:
20407
Publisher:
American Society for Clinical Investigation
Journal:
Journal of Clinical Investigation More from this journal
Volume:
129
Issue:
10
Pages:
4224-4238
Publication date:
2019-10-01
Acceptance date:
2019-07-03
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
Pmid:
31483286
Language:
English
Keywords:
Pubs id:
1049655
Local pid:
pubs:1049655
Deposit date:
2020-03-20

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