Journal article icon

Journal article

NR4A nuclear receptors target Poly-ADP-Ribosylated DNA-PKcs protein to promote DNA repair

Abstract:

Although poly-ADP-ribosylation (PARylation) of DNA repair factors had been well documented, its role in the repair of DNA double-strand breaks (DSBs) is poorly understood. NR4A nuclear orphan receptors were previously linked to DSB repair; however, their function in the process remains elusive. Classically, NR4As function as transcription factors using a specialized tandem zinc-finger DNA-binding domain (DBD) for target gene induction. Here, we show that NR4A DBD is bi-functional and can bind...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

Actions


Access Document


Files:
Publisher copy:
10.1016/j.celrep.2019.01.083

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
Expand authors...
Publisher:
Elsevier Publisher's website
Journal:
Cell Reports Journal website
Volume:
26
Issue:
8
Pages:
2028-2036
Publication date:
2019-02-19
Acceptance date:
2019-01-23
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
Pubs id:
pubs:976024
URN:
uri:1e21edaf-15ff-4a40-8f7a-53cfdba8c2a3
UUID:
uuid:1e21edaf-15ff-4a40-8f7a-53cfdba8c2a3
Local pid:
pubs:976024

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP