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A novel human pain insensitivity disorder caused by a point mutation in ZFHX2

Abstract:

Chronic pain is a major global public health issue causing a severe impact on both the quality of life for sufferers and the wider economy. Despite the significant clinical burden, little progress has been made in terms of therapeutic development. A unique approach to identifying new human-validated analgesic drug targets is to study rare families with inherited pain insensitivity. Here we have analysed an otherwise normal family where six affected individuals display a pain insensitive pheno...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/brain/awx326

Authors


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Role:
Author
ORCID:
0000-0001-8186-0333
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Name:
Wellcome Trust
Funding agency for:
Bennett, DLH
Grant:
202747/Z/16/Z
202747/Z/16/Z
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Name:
Department of Health
Grant:
NF-SI-0515-10082
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Name:
Rosetrees Trust
Grant:
M584
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Name:
Versus Arthritis
Grant:
20200
More from this funder
Name:
Arthritis Research UK
Grant:
20200
Publisher:
Oxford University Press
Journal:
Brain More from this journal
Volume:
141
Issue:
2
Pages:
365-376
Publication date:
2017-12-14
Acceptance date:
2017-10-18
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
Pmid:
29253101
Language:
English
Keywords:
Pubs id:
pubs:812264
UUID:
uuid:1e1fe089-ff2a-45ec-9258-f249ffcf055d
Local pid:
pubs:812264
Source identifiers:
812264
Deposit date:
2018-10-05

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