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Thesis

Network pharmacology of the MPP+ cellular model of Parkinson’s disease

Abstract:

Parkinson's disease (PD) is an incurable neurodegenerative motor disorder caused by the inexorable loss of dopamine neurones from the substantia nigra pars compacta. Cell loss is characterised by the perturbation of multiple physiological processes (including mitochondrial function, autophagy and dopamine homeostasis) and much of this pathophysiology can be reproduced in vitro using the mitochondrial toxin MPP+ (1-methyl-4-phenylpyridinium). It was hypothesised that MPP+ toxicity ...

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Institution:
University of Oxford
Research group:
Wade-Martins
Oxford college:
St Anne's College
Department:
Medical Sciences Division - Physiology,Anatomy and Genetics,Department of
Role:
Author

Contributors

Role:
Supervisor
Role:
Supervisor
Role:
Supervisor
Role:
Supervisor
Publication date:
2015
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:1e18e521-c1a3-4f1b-9572-9c68e0f16c2f
Local pid:
ora:10121

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