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Practical help for specifying the target difference in sample size calculations for RCTs: the DELTA2 five-stage study, including a workshop

Abstract:

Background: The randomised controlled trial is widely considered to be the gold standard study for comparing the effectiveness of health interventions. Central to its design is a calculation of the number of participants needed (the sample size) for the trial. The sample size is typically calculated by specifying the magnitude of the difference in the primary outcome between the intervention effects for the population of interest. This difference is called the ‘target di... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3310/hta23600

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Centre for Statistics in Medicine
Oxford college:
St Hugh's College
Role:
Author
ORCID:
0000-0002-4156-6989
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Role:
Author
ORCID:
0000-0002-9917-7636
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Role:
Author
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Publisher:
NIHR Journals Library Publisher's website
Journal:
Health Technology Assessment Journal website
Volume:
23
Issue:
60
Pages:
1-88
Publication date:
2019-10-01
Acceptance date:
2019-06-14
DOI:
EISSN:
2046-4924
ISSN:
1366-5278
Source identifiers:
1068820
Language:
English
Keywords:
Pubs id:
pubs:1068820
UUID:
uuid:1df07cd2-1a9d-41ef-ade6-4d6c6f6d250c
Local pid:
pubs:1068820
Deposit date:
2019-10-31

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