Journal article
Expression of TLR4-PTGE2 signaling genes in atherosclerotic carotid plaques and peripheral blood
- Abstract:
- Toll-like receptor 4 (TLR4)/prostaglandine synthetase 2 (PTGS2) signaling plays a relevant role in atherosclerotic plaque vulnerability. The purpose of this study was to check the gene expression of 6 genes participating to TLR4/PTGS2 signaling (TLR4, PTGS2, ACSL4, PTGER3, PTGER4, and EPRAP) in carotid plaques and blood samples from the same individual and to evaluate these genes as biomarker of plaque progression. We investigated differential gene expression by qRT-PCR in 62 atherosclerotic patients' carotid plaques and corresponding blood sample. A very weak or no correlation was observed in the overall population or analyzing asymptomatic patients. These analyzed genes are most likely not suitable for inclusion in the clinical routine as biomarkers of plaque instability.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
-
-
(Preview, Accepted manuscript, pdf, 366.5KB, Terms of use)
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- Publisher copy:
- 10.1007/s11033-018-4478-z
Authors
- Publisher:
- Springer
- Journal:
- Molecular Biology Reports More from this journal
- Volume:
- 46
- Issue:
- 1
- Pages:
- 1317-1321
- Publication date:
- 2018-11-12
- Acceptance date:
- 2018-11-07
- DOI:
- EISSN:
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1573-4978
- ISSN:
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0301-4851
- Pmid:
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30421129
- Language:
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English
- Keywords:
- Pubs id:
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pubs:943654
- UUID:
-
uuid:1debd323-b01a-498e-b518-03412018362c
- Local pid:
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pubs:943654
- Source identifiers:
-
943654
- Deposit date:
-
2018-12-19
Terms of use
- Copyright holder:
- Springer Nature BV
- Copyright date:
- 2018
- Notes:
- © Springer Nature B.V. 2018. This is the accepted manuscript version of the article. The final version is available online from Springer at: 10.1007/s11033-018-4478-z
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