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Journal article

Association of somatotrophinomas with loss of alleles on chromosome 11 and with gsp mutations.

Abstract:

The molecular pathology of somatotrophinomas has been investigated by a combined search for dominant mutations of the gene encoding the Gs alpha protein and for recessive mutations involving chromosome 11q13, which contains the gene causing multiple endocrine neoplasia type 1 (MEN1). Somatotrophinomas and peripheral leukocytes were obtained from thirteen patients with acromegaly; one patient also suffered from MEN1. Five DNA probes identifying restriction fragment length polymorphisms from 11...

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Publication status:
Published

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Publisher copy:
10.1172/jci116524

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
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Journal:
Journal of clinical investigation
Volume:
91
Issue:
6
Pages:
2815-2821
Publication date:
1993-06-01
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
Source identifiers:
27277

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