- Abstract:
-
The molecular pathology of somatotrophinomas has been investigated by a combined search for dominant mutations of the gene encoding the Gs alpha protein and for recessive mutations involving chromosome 11q13, which contains the gene causing multiple endocrine neoplasia type 1 (MEN1). Somatotrophinomas and peripheral leukocytes were obtained from thirteen patients with acromegaly; one patient also suffered from MEN1. Five DNA probes identifying restriction fragment length polymorphisms from 11...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1172/jci116524
-
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- Journal:
- The Journal of clinical investigation
- Volume:
- 91
- Issue:
- 6
- Pages:
- 2815-2821
- Publication date:
- 1993-06-05
- DOI:
- EISSN:
-
1558-8238
- ISSN:
-
0021-9738
- URN:
-
uuid:1dd6e991-3f21-4b87-b2e6-bf9af3510985
- Source identifiers:
-
27277
- Local pid:
- pubs:27277
- Language:
- English
- Keywords:
- Copyright date:
- 1993
Journal article
Association of somatotrophinomas with loss of alleles on chromosome 11 and with gsp mutations.
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