Journal article
Catalyst selection facilitates the use of heterocyclic sulfinates as general nucleophilic coupling partners in palladium-catalyzed coupling reactions
- Abstract:
- A range of 5- and 6-membered heterocycle-derived sulfinates are shown to be effective nucleophilic coupling partners with aryl chlorides and bromides using Pd(0) catalysis. The use of optimal reaction conditions, specifically incorporating a P(tBu)2Me-derived Pd catalyst, allowed reactions to be performed at moderate temperatures and enabled the inclusion of a variety of sensitive functional groups. Challenging heterocyclic sulfinates, including pyrazine, pyridazine, pyrimidine, pyrazole and imidazole were all shown to perform well.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, pdf, 392.0KB, Terms of use)
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(Preview, Accepted manuscript, pdf, 209.8KB, Terms of use)
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- Publisher copy:
- 10.1021/acs.orglett.7b02944
Authors
- Publisher:
- American Chemical Society
- Journal:
- Organic Letters More from this journal
- Volume:
- 19
- Issue:
- 22
- Pages:
- 6033–6035
- Publication date:
- 2017-10-18
- Acceptance date:
- 2017-10-11
- DOI:
- EISSN:
-
1523-7052
- ISSN:
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1523-7060
- Pubs id:
-
pubs:735164
- UUID:
-
uuid:1dca1f5f-9538-4ca4-bb30-aa604191549d
- Local pid:
-
pubs:735164
- Source identifiers:
-
735164
- Deposit date:
-
2017-10-12
Terms of use
- Copyright holder:
- American Chemical Society
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 American Chemical Society. A correction was added to this record on 6 September 2018. This is the accepted manuscript version of the article. The final version is available online from American Chemical Society at: 10.1021/acs.orglett.7b02944
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