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Journal article

Epistasis among HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibility.

Abstract:

Multiple sclerosis (MS), a common central nervous system inflammatory disease, has a major heritable component. Susceptibility is associated with the MHC class II region, especially HLA-DRB5*0101-HLA-DRB1*1501-HLA-DQA1*0102-HLA-DQB1*0602 haplotypes(hereafter DR2), which dominate genetic contribution to MS risk. Marked linkage disequilibrium (LD) among these loci makes identification of a specific locus difficult. The once-leading candidate, HLA-DRB1*15, localizes to risk, neutral, and protect...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0812664106

Authors


Lincoln, MR More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Herrera, BM More by this author
Deluca, GC More by this author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
106
Issue:
18
Pages:
7542-7547
Publication date:
2009-05-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:1dac3484-79f6-4b7d-9bd0-7af86488ce29
Source identifiers:
34692
Local pid:
pubs:34692

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