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Heterochronicity of white matter development and aging explains regional patient control differences in schizophrenia

Abstract:

Background

Altered brain connectivity is implicated in the development and clinical burden of schizophrenia. Relative to matched controls, schizophrenia patients show (1) a global and regional reduction in the integrity of the brain’s white matter (WM), assessed using diffusion tensor imaging (DTI) fractional anisotropy (FA), and (2) accelerated age-related decline in FA values. In the largest mega-analysis to date, we tested if differences in the trajectories of WM tract develop...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1002/hbm.23336

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Role:
Author
ORCID:
0000-0002-4169-9781
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Publisher:
Wiley Publisher's website
Journal:
Human Brain Mapping Journal website
Volume:
37
Issue:
12
Pages:
4673-4688
Publication date:
2016-08-01
Acceptance date:
2016-07-24
DOI:
EISSN:
1097-0193
ISSN:
1065-9471
Pubs id:
pubs:638225
URN:
uri:1d9671af-5567-443a-b82c-02cbbbbb4ba4
UUID:
uuid:1d9671af-5567-443a-b82c-02cbbbbb4ba4
Local pid:
pubs:638225

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