Recombinant viral vaccines for cancer

Journal article

Cancer arises from 'self' in a series of steps that are all subject to immunoediting. Therefore, therapeutic cancer vaccines must stimulate an immune response against tumour antigens that have already evaded the body's immune defences. Vaccines presenting a tumour antigen in the context of obvious danger signals seem more likely to stimulate a response. This approach can be facilitated by genetic engineering using recombinant viral vectors expressing tumour antigens, cytokines, or both, from ...

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Authors: Cawood, R; Hills, T; Wong, S; Alamoudi, A; Beadle, S

• Journal: Trends in Molecular Medicine
• Volume: 18
• Issue: 9
• Pages: 564-574
• Publication date: 2012-09-01
• DOI: 10.1016/j.molmed.2012.07.007
• EISSN: 1471-499X
• ISSN: 1471-4914
• Language: English
• Keywords: Tumour-associated antigens; Cancer vaccines; Cancer vaccination; Tumour microenvironment; Genetic vaccines; Cancer immunity; Recombinant viruses