Journal article

Catastrophic hyperkalaemia following administration of suxamethonium chloride to a patient with undiagnosed amyotrophic lateral sclerosis.

Abstract:: The depolarising neuromuscular blocking agent suxamethonium chloride, frequently used during endotracheal intubation, is contraindicated in patients with chronic denervation in whom it can cause a life-threatening hyperkalaemic reaction, thought to be mediated through upregulation of nicotinic alpha7 acetylcholine receptors. An underlying neuromuscular disorder should be considered in all patients with acute respiratory insufficiency, and an alternative neuromuscular blocking drug must be used if there is any possibility of widespread denervation.

Publication status:: Published

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APA Style

Turner, M., Lawrence, H., Arnold, I., Ansorge, O., & Talbot, K. (2011). Catastrophic hyperkalaemia following administration of suxamethonium chloride to a patient with undiagnosed amyotrophic lateral sclerosis. Clinical Medicine (London, England), 11(3), 292–293.

MLA Style

Turner, M., et al. “Catastrophic Hyperkalaemia Following Administration of Suxamethonium Chloride to a Patient with Undiagnosed Amyotrophic Lateral Sclerosis.” Clinical Medicine (London, England), vol. 11, no. 3, 2011, pp. 292–93.

Chicago Style

Turner, M, H Lawrence, I Arnold, O Ansorge, and K Talbot. 2011. “Catastrophic Hyperkalaemia Following Administration of Suxamethonium Chloride to a Patient with Undiagnosed Amyotrophic Lateral Sclerosis.” Clinical Medicine (London, England) 11 (3): 292–93.
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Publisher copy:: 10.7861/clinmedicine.11-3-292

Authors

+ Turner, M More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Clinical Neurosciences
Role:: Author

+ Lawrence, H More by this author

Role:: Author

+ Arnold, I More by this author

Role:: Author

+ Ansorge, O More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Clinical Neurosciences
Role:: Author

+ Talbot, K More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Clinical Neurosciences
Role:: Author

Journal:: Clinical medicine (London, England) More from this journal
Volume:: 11
Issue:: 3
Pages:: 292-293
Publication date:: 2011-06-01
DOI:: 10.7861/clinmedicine.11-3-292
EISSN:: 1473-4893
ISSN:: 1470-2118

Language:: English
Keywords:: Middle Aged

Tachycardia

Neuromuscular Depolarizing Agents

Intubation, Intratracheal

Succinylcholine

Humans

Amyotrophic Lateral Sclerosis

Fasciculation

Hyperkalemia

Fatal Outcome

Female
Pubs id:: pubs:241525
UUID:: uuid:1d7526b1-c8b8-4ed4-9cf0-93d328d5397b
Local pid:: pubs:241525
Source identifiers:: 241525
Deposit date:: 2012-12-19

Terms of use

Copyright date:: 2011

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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