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Catastrophic hyperkalaemia following administration of suxamethonium chloride to a patient with undiagnosed amyotrophic lateral sclerosis.

Abstract:

The depolarising neuromuscular blocking agent suxamethonium chloride, frequently used during endotracheal intubation, is contraindicated in patients with chronic denervation in whom it can cause a life-threatening hyperkalaemic reaction, thought to be mediated through upregulation of nicotinic alpha7 acetylcholine receptors. An underlying neuromuscular disorder should be considered in all patients with acute respiratory insufficiency, and an alternative neuromuscular blocking drug must be use...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Journal:
Clinical medicine (London, England) More from this journal
Volume:
11
Issue:
3
Pages:
292-293
Publication date:
2011-06-01
DOI:
EISSN:
1473-4893
ISSN:
1470-2118
Language:
English
Keywords:
Pubs id:
pubs:241525
UUID:
uuid:1d7526b1-c8b8-4ed4-9cf0-93d328d5397b
Local pid:
pubs:241525
Source identifiers:
241525
Deposit date:
2012-12-19

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