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Journal article : Review

Exploiting azide-alkyne click chemistry in the synthesis, tracking and targeting of platinum anticancer complexes.

Abstract:

Click chemistry is fundamentally important to medicinal chemistry and chemical biology. It represents a powerful and versatile tool, which can be exploited to develop novel Pt-based anticancer drugs and to better understand the biological effects of Pt-based anticancer drugs at a cellular level. Innovative azide–alkyne cycloaddition–based approaches are being used to functionalise Pt-based complexes with biomolecules to enhance tumour targeting. Valuable information in relation to the mechani...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Inorganic Chemistry
Role:
Author
ORCID:
0000-0002-7440-1291
More from this funder
Name:
Wellcome Trust
Grant:
201406/Z/16/Z
More from this funder
Name:
Medical Research Council
Grant:
letter dated 3 Sep 14
Publisher:
Elsevier
Journal:
Current Opinion in Chemical Biology More from this journal
Volume:
55
Pages:
59-68
Publication date:
2020-01-13
Acceptance date:
2019-12-02
DOI:
EISSN:
1879-0402
ISSN:
1367-5931
Pmid:
31945705
Language:
English
Keywords:
Subtype:
Review
Pubs id:
1083899
Local pid:
pubs:1083899
Deposit date:
2020-07-21

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