Exploiting azide-alkyne click chemistry in the synthesis, tracking and targeting of platinum anticancer complexes.

Journal article : Review

Click chemistry is fundamentally important to medicinal chemistry and chemical biology. It represents a powerful and versatile tool, which can be exploited to develop novel Pt-based anticancer drugs and to better understand the biological effects of Pt-based anticancer drugs at a cellular level. Innovative azide–alkyne cycloaddition–based approaches are being used to functionalise Pt-based complexes with biomolecules to enhance tumour targeting. Valuable information in relation to the mechanisms of action and resistance of Pt-based drugs is also being revealed through click-based detection, isolation and tracking of Pt drug surrogates in biological and cellular environments. Although less well-explored, inorganic Pt-click reactions enable synthesis of novel (potentially multimetallic) Pt complexes and provide plausible routes to introduce functional groups and monitoring Pt-azido drug localisation.

Authors: Farrer, NJ; Griffith, DM

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Elsevier
• Journal: Current Opinion in Chemical Biology
• Volume: 55
• Pages: 59-68
• Publication date: 2020-01-13
• Acceptance date: 2019-12-02
• DOI: 10.1016/j.cbpa.2019.12.001
• EISSN: 1879-0402
• ISSN: 1367-5931
• Pmid: 31945705
• Language: English
• Keywords: CuAAC; FFR; anticancer; synthesis; functionalise; azide; track; alkyne; cycloaddition; triazole; target; platinum; SPAAC; iClick; analyse
• Subtype: Review