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Journal article

Influences on the design and purification of soluble, recombinant native-like HIV-1 envelope glycoprotein trimers

Abstract:

We have investigated factors that influence the production of native-like soluble, recombinant trimers based on the env genes of two isolates of human immunodeficiency virus type 1 (HIV-1), specifically 92UG037.8 (clade A) and CZA97.012 (clade C). When the recombinant trimers based on the env genes of isolates 92UG037.8 and CZA97.012 were made according to the SOSIP.664 design and purified by affinity chromatography using broadly neutralizing antibodies (bNAbs) against quaternary epitopes (PG...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/JVI.01768-15

Authors


Yasmeen, A More by this author
Ozorowski, G More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
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Collaboration for AIDS Vaccine Discovery More from this funder
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Publisher:
American Society for Microbiology Publisher's website
Journal:
Journal of Virology Journal website
Volume:
89
Issue:
23
Pages:
12189-12210
Publication date:
2015-12-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:1d5819b6-c054-4c53-bd4d-4cceea4ca520
Source identifiers:
592893
Local pid:
pubs:592893

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