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An extracellular steric seeding mechanism for Eph-ephrin signaling platform assembly.

Abstract:

Erythropoetin-producing hepatoma (Eph) receptors are cell-surface protein tyrosine kinases mediating cell-cell communication. Upon activation, they form signaling clusters. We report crystal structures of the full ectodomain of human EphA2 (eEphA2) both alone and in complex with the receptor-binding domain of the ligand ephrinA5 (ephrinA5 RBD). Unliganded eEphA2 forms linear arrays of staggered parallel receptors involving two patches of residues conserved across A-class Ephs. eEphA2-ephrinA5...

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Publication status:
Published

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Publisher copy:
10.1038/nsmb.1782

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
Journal:
Nature structural and molecular biology More from this journal
Volume:
17
Issue:
4
Pages:
398-402
Publication date:
2010-04-01
DOI:
EISSN:
1545-9985
ISSN:
1545-9993
Language:
English
Keywords:
Pubs id:
pubs:51909
UUID:
uuid:1d538a14-286e-4f9e-91aa-cc526af51e59
Local pid:
pubs:51909
Source identifiers:
51909
Deposit date:
2012-12-19

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