Journal article
An extracellular steric seeding mechanism for Eph-ephrin signaling platform assembly.
- Abstract:
-
Erythropoetin-producing hepatoma (Eph) receptors are cell-surface protein tyrosine kinases mediating cell-cell communication. Upon activation, they form signaling clusters. We report crystal structures of the full ectodomain of human EphA2 (eEphA2) both alone and in complex with the receptor-binding domain of the ligand ephrinA5 (ephrinA5 RBD). Unliganded eEphA2 forms linear arrays of staggered parallel receptors involving two patches of residues conserved across A-class Ephs. eEphA2-ephrinA5...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- Nature structural and molecular biology
- Volume:
- 17
- Issue:
- 4
- Pages:
- 398-402
- Publication date:
- 2010-04-01
- DOI:
- EISSN:
-
1545-9985
- ISSN:
-
1545-9993
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:51909
- UUID:
-
uuid:1d538a14-286e-4f9e-91aa-cc526af51e59
- Local pid:
- pubs:51909
- Source identifiers:
-
51909
- Deposit date:
- 2012-12-19
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- Copyright date:
- 2010
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