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Remote targeted implantation of sound-sensitive biodegradable multi-cavity microparticles with focused ultrasound

Abstract:

Ultrasound-enhanced drug delivery has shown great promise in providing targeted burst release of drug at the site of the disease. Yet current solid ultrasound-responsive particles are non-degradable with limited potential for drug-loading. Here, we report on an ultrasound-responsive multi-cavity poly(lactic-co-glycolic acid) microparticle (mcPLGA MP) loaded with rhodamine B (RhB) with or without 4′,6-diamidino-2-phenylindole (DAPI) to represent small molecule therapeutics. After exposure to h...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41598-019-46022-0

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Role:
Author
ORCID:
0000-0002-8303-6660
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Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Oxford college:
Balliol College
Role:
Author
ORCID:
0000-0002-3795-6108
Publisher:
Springer Nature
Journal:
Scientific Reports More from this journal
Volume:
9
Article number:
9612
Publication date:
2019-07-03
Acceptance date:
2019-06-20
DOI:
EISSN:
2045-2322
Language:
English
Keywords:
Pubs id:
1122551
Local pid:
pubs:1122551
Deposit date:
2020-08-04

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