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Nuclear fate of yeast snoRNA is determined by co-transcriptional Rnt1 cleavage

Abstract:

Small nucleolar RNA (snoRNA) are conserved and essential non-coding RNA that are transcribed by RNA Polymerase II (Pol II). Two snoRNA classes, formerly distinguished by their structure and ribonucleoprotein composition, act as guide RNA to target RNA such as ribosomal RNA, and thereby introduce specific modifications. We have studied the 5'end processing of individually transcribed snoRNA in S. cerevisiae to define their role in snoRNA biogenesis and functionality. Here we show that pre-snoR...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41467-018-04094-y

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
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Polish Ministry of Science and Higher Education More from this funder
Polish-Swiss Research Programme More from this funder
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Issue:
1
Pages:
1783
Publication date:
2018-05-03
Acceptance date:
2018-04-04
DOI:
EISSN:
2041-1723
Pubs id:
pubs:847746
URN:
uri:1d0816e3-cc64-4345-8c6a-71487f3bbdd3
UUID:
uuid:1d0816e3-cc64-4345-8c6a-71487f3bbdd3
Local pid:
pubs:847746
Language:
English
Keywords:

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