Journal article icon

Journal article

Semi-allogeneic dendritic cells can induce antigen-specific T-cell activation, which is not enhanced by concurrent alloreactivity.

Abstract:

BACKGROUND: Alloreactive T-cell responses are known to result in the production of large amounts of proinflammatory cytokines capable of activating and maturing dendritic cells (DC). However, it is unclear whether these allogeneic responses could also act as an adjuvant for concurrent antigen-specific responses. OBJECTIVE: To examine effects of simultaneous alloreactive and antigen-specific T-cell responses induced by semi-allogeneic DC. METHODS: Semi-allogeneic DC were generated from the F(...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1007/s00262-007-0328-x

Authors


Cowled, CJ More by this author
Darling, D More by this author
Farzaneh, F More by this author
Expand authors...
Journal:
Cancer immunology, immunotherapy : CII
Volume:
56
Issue:
12
Pages:
1861-1873
Publication date:
2007-12-05
DOI:
EISSN:
1432-0851
ISSN:
0340-7004
URN:
uuid:1cea4134-4a26-4cad-a73f-22d6644f3c23
Source identifiers:
466382
Local pid:
pubs:466382

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP