- Abstract:
-
BACKGROUND: Alloreactive T-cell responses are known to result in the production of large amounts of proinflammatory cytokines capable of activating and maturing dendritic cells (DC). However, it is unclear whether these allogeneic responses could also act as an adjuvant for concurrent antigen-specific responses. OBJECTIVE: To examine effects of simultaneous alloreactive and antigen-specific T-cell responses induced by semi-allogeneic DC. METHODS: Semi-allogeneic DC were generated from the F(...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1007/s00262-007-0328-x
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- Journal:
- Cancer immunology, immunotherapy : CII
- Volume:
- 56
- Issue:
- 12
- Pages:
- 1861-1873
- Publication date:
- 2007-12-05
- DOI:
- EISSN:
-
1432-0851
- ISSN:
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0340-7004
- URN:
-
uuid:1cea4134-4a26-4cad-a73f-22d6644f3c23
- Source identifiers:
-
466382
- Local pid:
- pubs:466382
- Copyright date:
- 2007
Journal article
Semi-allogeneic dendritic cells can induce antigen-specific T-cell activation, which is not enhanced by concurrent alloreactivity.
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