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Toward a broader view of mechanisms of drug cardiotoxicity

Abstract:

Cardiotoxicity, defined as toxicity that affects the heart, is one of the most common adverse drug effects. Numerous drugs have been shown to have the potential to induce lethal arrhythmias by affecting cardiac electrophysiology, which is the focus of current preclinical testing. However, a substantial number of drugs can also affect cardiac function beyond electrophysiology. Within this broader sense of cardiotoxicity, this review discusses the key drug-protein interactions known to be invol...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.xcrm.2021.100216

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Computer Science
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Computer Science
Oxford college:
Keble College
Role:
Author
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Name:
British Heart Foundation
Grant:
FS/17/22/32644
Publisher:
Cell Press
Journal:
Cell Reports Medicine More from this journal
Volume:
2
Issue:
3
Article number:
100216
Publication date:
2021-03-16
Acceptance date:
2021-02-12
DOI:
EISSN:
2666-3791
Language:
English
Keywords:
Pubs id:
1161194
Local pid:
pubs:1161194
Deposit date:
2021-02-13

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