Toward a broader view of mechanisms of drug cardiotoxicity

Journal article

Cardiotoxicity, defined as toxicity that affects the heart, is one of the most common adverse drug effects. Numerous drugs have been shown to have the potential to induce lethal arrhythmias by affecting cardiac electrophysiology, which is the focus of current preclinical testing. However, a substantial number of drugs can also affect cardiac function beyond electrophysiology. Within this broader sense of cardiotoxicity, this review discusses the key drug-protein interactions known to be involved in cardiotoxic drug response. We cover adverse effects of anticancer, central nervous system, genitourinary system, gastrointestinal, antihistaminic, anti-inflammatory, and anti-infective agents, illustrating that many share mechanisms of cardiotoxicity, including contractility, mitochondrial function, and cellular signaling.

Authors: Mamoshina, P; Rodriguez, B; Bueno-Orovio, A

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Cell Press
• Journal: Cell Reports Medicine
• Volume: 2
• Issue: 3
• Article number: 100216
• Publication date: 2021-03-16
• Acceptance date: 2021-02-12
• DOI: 10.1016/j.xcrm.2021.100216
• EISSN: 2666-3791
• Language: English
• Keywords: side effects; adverse reactions; cell signalling; FFR; mechanisms of toxicity; cardiotoxicity