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Prevention with angiotensin-converting enzyme (ACE) inhibitors

Abstract:

Preventive therapy by angiotensin-converting-enzyme (ACE) inhibitors is considered in hypertension and, more recently, in chronic heart failure. The mechanism of action of ACE-inhibitors is complex; most extensively studied, however, is their inhibitory effect on angiotensin-II production. ACE-inhibitors may act as vasodilators, reducing pre- and afterload. On the other hand, local renin-angiotensin systems may control growth processes both in myocardial and in smooth muscle cells. This may b...

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Authors


Gaudron, P More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Journal:
Zeitschrift fur Kardiologie
Volume:
81 Suppl 4
Pages:
205-210
Publication date:
1992
ISSN:
0300-5860
URN:
uuid:1ccc63b3-6f45-4b2b-827a-a94bb32b7b8f
Source identifiers:
441478
Local pid:
pubs:441478
Language:
German

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