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Hepcidin is regulated by promoter-associated histone acetylation and HDAC3

Abstract:

Hepcidin regulates systemic iron homeostasis. Suppression of hepcidin expression occurs physiologically in iron deficiency (ID) and increased erythropoiesis but is pathologic in thalassaemia and haemochromatosis. Here we show that epigenetic events govern hepcidin expression. Erythropoiesis and ID suppress hepcidin via erythroferrone-dependent and -independent mechanisms respectively in vivo, but both involve reversible loss of H3K9ac and H3K4me3 at the hepcidin locus. In vitro, pan-histone d...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM - Investigative Medicine Division
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM - Investigative Medicine Division
Role:
Author
More from this funder
Name:
Wellcome Trust
Funding agency for:
Draper, S
Ashley, N
Grant:
106917/Z/15/Z
MR/M00919X/1
More from this funder
Name:
Lister Institute
Funding agency for:
Draper, S
Grant:
106917/Z/15/Z
More from this funder
Name:
Jenner Institute
Funding agency for:
Draper, S
Grant:
106917/Z/15/Z
More from this funder
Name:
Medical Research Council
Funding agency for:
Lim, P
Al-Hourani, K
Wray, K
Ashley, N
Armitage, A
Drakesmith, A
Grant:
MR/M00919X/1
More from this funder
Name:
European Regional Development Fund
Grant:
Norte-01-0145-FEDER-756 000012
Publisher:
Nature Publishing Group
Journal:
Nature Communications More from this journal
Volume:
8
Pages:
403
Publication date:
2017-09-01
Acceptance date:
2017-07-04
DOI:
EISSN:
2041-1723
Keywords:
Pubs id:
pubs:702961
UUID:
uuid:1cc91d22-8743-435b-97b0-b17588268d95
Local pid:
pubs:702961
Source identifiers:
702961
Deposit date:
2017-07-04

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