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Hepcidin is regulated by promoter-associated histone acetylation and HDAC3

Abstract:

Hepcidin regulates systemic iron homeostasis. Suppression of hepcidin expression occurs physiologically in iron deficiency (ID) and increased erythropoiesis but is pathologic in thalassaemia and haemochromatosis. Here we show that epigenetic events govern hepcidin expression. Erythropoiesis and ID suppress hepcidin via erythroferrone-dependent and -independent mechanisms respectively in vivo, but both involve reversible loss of H3K9ac and H3K4me3 at the hepcidin locus. In vitro, pan-histone d...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41467-017-00500-z

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Department:
Oxford, MSD, RDM, RDM - Investigative Medicine Division
Role:
Author
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Department:
Oxford, MSD, RDM, RDM - Investigative Medicine Division
Role:
Author
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Funding agency for:
Pasricha, S-RS
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
8
Pages:
403
Publication date:
2017-09-05
Acceptance date:
2017-07-04
DOI:
EISSN:
2041-1723
Pubs id:
pubs:702961
URN:
uri:1cc91d22-8743-435b-97b0-b17588268d95
UUID:
uuid:1cc91d22-8743-435b-97b0-b17588268d95
Local pid:
pubs:702961
Keywords:

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