The Tudor domain 'Royal Family': Tudor, plant Agenet, Chromo, PWWP and MBT domains.

Journal article

We have identified a family of 'Agenet' domains that are plant-specific homologs of Tudor domains. This finding has been extended, using a combination of sequence- and structure-dependent approaches, to show that the three beta-stranded core regions of Tudor, PWWP, chromatin-binding (Chromo) and MBT domains are homologous because they originate from a common ancestor. In addition, we have revealed pairs of tandem repeats in the fragile X mental retardation protein (FMRP) family that are also members of this Tudor domain 'Royal Family'.

Authors: Maurer-Stroh, S; Dickens, N; Hughes-Davies, L; Kouzarides, T; Eisenhaber, F

• Journal: Trends in biochemical sciences
• Volume: 28
• Issue: 2
• Pages: 69-74
• Publication date: 2003-02-01
• DOI: 10.1016/s0968-0004(03)00004-5
• ISSN: 0968-0004
• Language: English
• Keywords: Models, Molecular; Protein Structure, Secondary; Sequence Homology, Amino Acid; Humans; Amino Acid Sequence; Drosophila Proteins; Arabidopsis; Animals; Minisatellite Repeats; Plant Proteins; Membrane Transport Proteins; Evolution, Molecular; Protein Structure, Tertiary; Insect Proteins; Molecular Sequence Data