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The Tudor domain 'Royal Family': Tudor, plant Agenet, Chromo, PWWP and MBT domains.

Abstract:
We have identified a family of 'Agenet' domains that are plant-specific homologs of Tudor domains. This finding has been extended, using a combination of sequence- and structure-dependent approaches, to show that the three beta-stranded core regions of Tudor, PWWP, chromatin-binding (Chromo) and MBT domains are homologous because they originate from a common ancestor. In addition, we have revealed pairs of tandem repeats in the fragile X mental retardation protein (FMRP) family that are also members of this Tudor domain 'Royal Family'.

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Authors


Maurer-Stroh, S More by this author
Dickens, NJ More by this author
Hughes-Davies, L More by this author
Kouzarides, T More by this author
Eisenhaber, F More by this author
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Journal:
Trends in biochemical sciences
Volume:
28
Issue:
2
Pages:
69-74
Publication date:
2003-02-05
DOI:
ISSN:
0968-0004
URN:
uuid:1cb146e4-0a4e-47d1-8066-bf30ea3ec26d
Source identifiers:
238136
Local pid:
pubs:238136

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