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UKPDS 25: autoantibodies to islet-cell cytoplasm and glutamic acid decarboxylase for prediction of insulin requirement in type 2 diabetes. UK Prospective Diabetes Study Group.

Abstract:

BACKGROUND: Autoantibodies to islet-cell cytoplasm (ICA) and glutamic acid decarboxylase (GADA) can occur in apparently typical, non-insulin dependent diabetes mellitus (type 2). We investigated whether the presence of either or both antibodies characterises a subtype of diabetes and provides better prediction of requirement for insulin therapy by 6 years' follow-up than clinical variables. METHODS: We measured ICA and GADA at diagnosis of diabetes in a representative population of 3672 white...

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Journal:
Lancet More from this journal
Volume:
350
Issue:
9087
Pages:
1288-1293
Publication date:
1997-11-01
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
Language:
English
Keywords:
Pubs id:
pubs:485323
UUID:
uuid:1cab5256-1e7c-4a2d-8842-3f05f05d7f52
Local pid:
pubs:485323
Source identifiers:
485323
Deposit date:
2014-09-30

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