Journal article
The relationship between spatial configuration and functional connectivity of brain regions revisited
- Abstract:
- Previously we showed that network-based modelling of brain connectivity interacts strongly with the shape and exact location of brain regions, such that cross-subject variations in the spatial configuration of functional brain regions are being interpreted as changes in functional connectivity (Bijsterbosch et al., 2018). Here we show that these spatial effects on connectivity estimates actually occur as a result of spatial overlap between brain networks. This is shown to systematically bias connectivity estimates obtained from group spatial ICA followed by dual regression. We introduce an extended method that addresses the bias and achieves more accurate connectivity estimates.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 3.9MB, Terms of use)
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- Publisher copy:
- 10.7554/eLife.44890
Authors
+ Wellcome Trust
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- Grant:
- 106183/Z/14/Z
- 091509/Z/10/Z
- 098369/Z/12/Z
- 203139/Z/16/Z
- Publisher:
- eLife Sciences Publications
- Journal:
- eLife More from this journal
- Volume:
- 8
- Article number:
- e44890
- Publication date:
- 2019-05-08
- Acceptance date:
- 2019-05-07
- DOI:
- ISSN:
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2050-084X
- Pmid:
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31066676
- Language:
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English
- Keywords:
- Pubs id:
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pubs:997861
- UUID:
-
uuid:1ca2c487-aa17-41ad-89b1-01c5ede3bdd3
- Local pid:
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pubs:997861
- Source identifiers:
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997861
- Deposit date:
-
2019-06-24
Terms of use
- Copyright holder:
- Bijsterbosch et al
- Copyright date:
- 2019
- Notes:
- © Copyright Bijsterbosch et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited
- Licence:
- CC Attribution (CC BY)
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