Journal article
Capturing the Molecular Mechanism of Anesthetic Action by Simulation Methods
- Abstract:
- Significant computational efforts have been focused toward exposing the molecular mechanisms of anesthesia in recent years. In the past decade, this has been aided considerably by a momentous increase in the number of high-resolution structures of ion channels, which are putative targets for the anesthetic agents, as well as advancements in high-performance computing technologies. In this review, typical simulation methods to investigate the behavior of model membranes and membrane-protein systems are briefly reviewed, and related computational studies are surveyed. Both lipid- and protein-mediated mechanisms of anesthetic action are scrutinized, focusing on the behavior of ion channels in the latter case.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Access Document
- Files:
-
-
(Preview, Accepted manuscript, pdf, 1.2MB, Terms of use)
-
- Publisher copy:
- 10.1021/acs.chemrev.8b00366
Authors
- Publisher:
- American Chemical Society
- Journal:
- Chemical Reviews More from this journal
- Volume:
- 119
- Issue:
- 9
- Pages:
- 5998-6014
- Publication date:
- 2018-10-25
- Acceptance date:
- 2018-10-22
- DOI:
- EISSN:
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1520-6890
- ISSN:
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0009-2665
- Pmid:
-
30358391
- Language:
-
English
- Keywords:
- Pubs id:
-
pubs:936637
- UUID:
-
uuid:1c9112f8-8ae1-4d00-9cd1-f9621ac5e3f6
- Local pid:
-
pubs:936637
- Source identifiers:
-
936637
- Deposit date:
-
2019-03-25
Terms of use
- Copyright holder:
- American Chemical Society
- Copyright date:
- 2018
- Notes:
- © 2018 American Chemical Society. This is the accepted manuscript version of the article. The final version is available online from the American Chemical Society at: https://doi.org/10.1021/acs.chemrev.8b00366
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