Journal article
Effect of supplementation with flaxseed oil and different doses of fish oil for two weeks on plasma phosphatidylcholine fatty acids in young women.
- Abstract:
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Background/Objective
Although assumed, it remains unclear that fatty acid (FA) biomarkers of n-3 long-chain PUFA reflect wide ranges of intake. However, to be utilised as biomarkers, to predict dietary intake, dose-response curves that cover a spectrum of intakes are required. The aim of the study was to investigate whether the FA composition of plasma phosphatidylcholine (PC) is a sensitive biomarker of n-3 FAs from fish oil, across a range of supplementation doses, and alpha-linolenic acid (ALA) supplementation, in young, healthy women.
Subjects/Methods
A total of 303 young women were randomized to intakes ranging between 0.33 and 4.50 g EPA+DHA/day from fish oil (not all doses used in each year) or flaxseed oil (5.90–6.60 g/day) daily for 14 days in a series of trials, over five years. Fasting blood was collected at baseline (Day 0) and day 14 and plasma PC FA composition, total and HDL-cholesterol and triacylglycerol concentrations measured.
Results
Fourteen days supplementation with fish oil significantly (P<0.01) increased, in a dose-dependent fashion, plasma PC EPA, DPA and DHA at all doses except 1 and 3 mL/day. For the combined group of women who consumed any fish oil there was a 16% (P<0.01) decrease in plasma triacylglycerol concentrations after 14 days supplementation. Flaxseed oil supplementation for 14 day resulted in significant (P<0.01) increases in ALA, EPA and DPA, whilst DHA remained unchanged.
Conclusion
Our data demonstrate plasma PC is a sensitive biomarker of n-3 FA intake and reflects changes within 14 days across a range of intakes.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 586.1KB, Terms of use)
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- Publisher copy:
- 10.1038/s41430-018-0174-2
Authors
- Publisher:
- Nature Publishing Group
- Journal:
- European Journal of Clinical Nutrition More from this journal
- Volume:
- 72
- Pages:
- 832–840
- Publication date:
- 2018-05-30
- Acceptance date:
- 2018-03-19
- DOI:
- EISSN:
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1476-5640
- ISSN:
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0954-3007
- Pubs id:
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pubs:830621
- UUID:
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uuid:1c89766f-604d-40ab-8682-ee0801624bc3
- Local pid:
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pubs:830621
- Source identifiers:
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830621
- Deposit date:
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2018-03-21
Terms of use
- Copyright holder:
- Hodson et al
- Copyright date:
- 2018
- Notes:
- © The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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