Journal article

Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials.

Abstract:: BACKGROUND: Alteplase is effective for treatment of acute ischaemic stroke but debate continues about its use after longer times since stroke onset, in older patients, and among patients who have had the least or most severe strokes. We assessed the role of these factors in affecting good stroke outcome in patients given alteplase. METHODS: We did a pre-specified meta-analysis of individual patient data from 6756 patients in nine randomised trials comparing alteplase with placebo or open cont...
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Publication status:: Published

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APA Style

Emberson, J., Lees, K., Lyden, P., Blackwell, L., Albers, G., Bluhmki, E., Brott, T., Cohen, G., Davis, S., Donnan, G., Grotta, J., Howard, G., Kaste, M., Koga, M., von Kummer, R., Lansberg, M., Lindley, R., Murray, G., Olivot, J., … Wardlaw, J. (2014). Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials. Lancet, 384(9958), 1929–1935.

MLA Style

Emberson, J, et al. “Effect of Treatment Delay, Age, and Stroke Severity on the Effects of Intravenous Thrombolysis with Alteplase for Acute Ischaemic Stroke: a Meta-Analysis of Individual Patient Data from Randomised Trials.” Lancet, vol. 384, no. 9958, 2014, pp. 1929–35.

Chicago Style

Emberson, J, K Lees, P Lyden, et al. 2014. “Effect of Treatment Delay, Age, and Stroke Severity on the Effects of Intravenous Thrombolysis with Alteplase for Acute Ischaemic Stroke: a Meta-Analysis of Individual Patient Data from Randomised Trials.” Lancet 384 (9958): 1929–35.
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Publisher copy:: 10.1016/s0140-6736(14)60584-5

Authors

+ Emberson, J More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Nuffield Department of Population Health
Sub department:: Clinical Trial Service Unit
Role:: Author

+ Lees, K More by this author

Role:: Author

+ Lyden, P More by this author

Role:: Author

+ Blackwell, L More by this author

Role:: Author

+ Albers, G More by this author

Role:: Author

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Journal:: Lancet More from this journal
Volume:: 384
Issue:: 9958
Pages:: 1929-1935
Publication date:: 2014-11-01
DOI:: 10.1016/s0140-6736(14)60584-5
EISSN:: 1474-547X
ISSN:: 0140-6736

Language:: English
Keywords:: Stroke Thrombolysis Trialists' Collaborative Group
Pubs id:: pubs:480712
UUID:: uuid:1c6ef266-ca95-4bc7-95c5-f90fd71f117d
Local pid:: pubs:480712
Source identifiers:: 480712
Deposit date:: 2014-08-21
ARK identifier:: ark:/29072/ora_1c6ef266ca954bc795c5f90fd71f117d

Terms of use

Copyright date:: 2014

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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