Journal article icon

Journal article

Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials.

Abstract:

BACKGROUND: Alteplase is effective for treatment of acute ischaemic stroke but debate continues about its use after longer times since stroke onset, in older patients, and among patients who have had the least or most severe strokes. We assessed the role of these factors in affecting good stroke outcome in patients given alteplase. METHODS: We did a pre-specified meta-analysis of individual patient data from 6756 patients in nine randomised trials comparing alteplase with placebo or open cont...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Trial Service Unit, BHF Centre of Research Excellence
Role:
Author
Expand authors...
Journal:
Lancet
Volume:
384
Issue:
9958
Pages:
1929-1935
Publication date:
2014-11-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:1c6ef266-ca95-4bc7-95c5-f90fd71f117d
Source identifiers:
480712
Local pid:
pubs:480712

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP