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Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials.

Abstract:

BACKGROUND: Alteplase is effective for treatment of acute ischaemic stroke but debate continues about its use after longer times since stroke onset, in older patients, and among patients who have had the least or most severe strokes. We assessed the role of these factors in affecting good stroke outcome in patients given alteplase. METHODS: We did a pre-specified meta-analysis of individual patient data from 6756 patients in nine randomised trials comparing alteplase with placebo or open cont...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
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Journal:
Lancet
Volume:
384
Issue:
9958
Pages:
1929-1935
Publication date:
2014-11-01
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
Source identifiers:
480712
Language:
English
Keywords:
Pubs id:
pubs:480712
UUID:
uuid:1c6ef266-ca95-4bc7-95c5-f90fd71f117d
Local pid:
pubs:480712
Deposit date:
2014-08-21

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