Journal article
Cotrimoxazole reduces systemic inflammation in HIV infection by altering the gut microbiome and immune activation
- Abstract:
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Long-term cotrimoxazole prophylaxis reduces mortality and morbidity in HIV infection, but the mechanisms underlying these clinical benefits are unclear. Here, we investigate the impact of cotrimoxazole on systemic inflammation, an independent driver of HIV mortality. In HIV-positive Ugandan and Zimbabwean children receiving antiretroviral therapy, we show that plasma inflammatory markers were lower after randomization to continue (n = 144) versus stop (n = 149) cotrimoxazole. This was not exp...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Access Document
- Files:
-
-
(Accepted manuscript, pdf, 3.7MB)
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- Publisher copy:
- 10.1126/scitranslmed.aav0537
Authors
Bibliographic Details
- Publisher:
- American Association for the Advancement of Science Publisher's website
- Journal:
- Science Translational Medicine
- Volume:
- 11
- Issue:
- 486
- Article number:
- eaav0537
- Publication date:
- 2019-04-03
- Acceptance date:
- 2019-02-14
- DOI:
- EISSN:
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1946-6242
- ISSN:
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1946-6234
Item Description
- Pubs id:
-
pubs:974033
- UUID:
-
uuid:1c67b7c7-be79-4c41-82b4-318c0bf9676b
- Local pid:
- pubs:974033
- Source identifiers:
-
974033
- Deposit date:
- 2019-02-16
Terms of use
- Copyright holder:
- Bourke et al
- Copyright date:
- 2019
- Notes:
- © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. This is the accepted manuscript version of the article. The final version is available online from American Association for the Advancement of Science at: 10.1126/scitranslmed.aav0537
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