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Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.

Abstract:

Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3,...

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Publication status:
Published

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Publisher copy:
10.1038/ng.685

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Journal:
Nature genetics
Volume:
42
Issue:
11
Pages:
949-960
Publication date:
2010-11-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:1c452abd-6acb-4613-b6d3-721814cca555
Source identifiers:
90289
Local pid:
pubs:90289

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