Conference item
AMP-activated protein kinase phosphorylates cardiac troponin I and alters contractility of murine ventricular myocytes.
- Abstract:
-
RATIONALE: AMP-activated protein kinase (AMPK) is an important regulator of energy balance and signaling in the heart. Mutations affecting the regulatory γ2 subunit have been shown to cause an essentially cardiac-restricted phenotype of hypertrophy and conduction disease, suggesting a specific role for this subunit in the heart. OBJECTIVE: The γ isoforms are highly conserved at their C-termini but have unique N-terminal sequences, and we hypothesized that the N-terminus of γ2 may be involved ...
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- Publication status:
- Published
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- Publisher copy:
- 10.1161/circresaha.111.259952
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Bibliographic Details
- Volume:
- 110
- Issue:
- 9
- Pages:
- 1192-1201
- Host title:
- Circulation research
- Publication date:
- 2012-04-01
- Event location:
- United States
- DOI:
- EISSN:
-
1524-4571
- ISSN:
-
0009-7330
- Source identifiers:
-
104349
Item Description
- Keywords:
- Pubs id:
-
pubs:104349
- UUID:
-
uuid:1c4383ac-5d70-417a-b4ec-3eb7e9329c90
- Local pid:
- pubs:104349
- Deposit date:
- 2012-12-19
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- Copyright date:
- 2012
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