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AMP-activated protein kinase phosphorylates cardiac troponin I and alters contractility of murine ventricular myocytes.

Abstract:

RATIONALE: AMP-activated protein kinase (AMPK) is an important regulator of energy balance and signaling in the heart. Mutations affecting the regulatory γ2 subunit have been shown to cause an essentially cardiac-restricted phenotype of hypertrophy and conduction disease, suggesting a specific role for this subunit in the heart. OBJECTIVE: The γ isoforms are highly conserved at their C-termini but have unique N-terminal sequences, and we hypothesized that the N-terminus of γ2 may be involved ...

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Publication status:
Published

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Volume:
110
Issue:
9
Pages:
1192-1201
Host title:
Circulation research
Publication date:
2012-04-01
Event location:
United States
DOI:
EISSN:
1524-4571
ISSN:
0009-7330
Source identifiers:
104349

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