Temporal changes in SARS-CoV-2 clearance kinetics and the optimal design of antiviral pharmacodynamic studies: an individual patient data meta-analysis of a randomised, controlled, adaptive platform study (PLATCOV)

Wongnak, P; Schilling, WHK; Jittamala, P; Boyd, S; Luvira, V; Siripoon, T; Ngamprasertchai, T; Batty, EM; Singh, S; Kouhathong, J; Pagornrat, W; Khanthagan, P; Hanboonkunupakarn, B; Poovorawan, K; Mayxay, M; Chotivanich, K; Imwong, M; Pukrittayakamee, S; Ashley, EA; Dondorp, AM; Day, NPJ; Teixeira, MM; Piyaphanee, W; Phumratanaprapin, W; White, NJ; Watson, JA

Journal article

Temporal changes in SARS-CoV-2 clearance kinetics and the optimal design of antiviral pharmacodynamic studies: an individual patient data meta-analysis of a randomised, controlled, adaptive platform study (PLATCOV)

Abstract:: Background
Effective antiviral drugs prevent hospitalisation and death from COVID-19. Antiviral efficacy can be efficiently assessed in vivo by measuring rates of SARS-CoV-2 clearance estimated from serial viral genome densities quantitated in nasopharyngeal or oropharyngeal swab eluates. We conducted an individual patient data meta-analysis of unblinded arms in the PLATCOV platform trial to characterise changes in viral clearance kinetics and infer optimal design and ... Expand abstract
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Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Wongnak, P., Schilling, W. H. K., Jittamala, P., Boyd, S., Luvira, V., Siripoon, T., Ngamprasertchai, T., Batty, E. M., Singh, S., Kouhathong, J., Pagornrat, W., Khanthagan, P., Hanboonkunupakarn, B., Poovorawan, K., Mayxay, M., Chotivanich, K., Imwong, M., Pukrittayakamee, S., Ashley, E. A., … Watson, J. A. (2024). Temporal changes in SARS-CoV-2 clearance kinetics and the optimal design of antiviral pharmacodynamic studies: an individual patient data meta-analysis of a randomised, controlled, adaptive platform study (PLATCOV). Lancet Infectious Diseases, 24(9), P953–963.

MLA Style

Wongnak, P., et al. “Temporal Changes in SARS-CoV-2 Clearance Kinetics and the Optimal Design of Antiviral Pharmacodynamic Studies: an Individual Patient Data Meta-Analysis of a Randomised, Controlled, Adaptive Platform Study (PLATCOV).” Lancet Infectious Diseases, vol. 24, no. 9, Elsevier, 2024, pp. P953–963.

Chicago Style

Wongnak, P, WHK Schilling, P Jittamala, S Boyd, V Luvira, T Siripoon, T Ngamprasertchai, et al. 2024. “Temporal Changes in SARS-CoV-2 Clearance Kinetics and the Optimal Design of Antiviral Pharmacodynamic Studies: an Individual Patient Data Meta-Analysis of a Randomised, Controlled, Adaptive Platform Study (PLATCOV).” Lancet Infectious Diseases 24 (9): P953–963.
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