Structure and function of matrix metalloproteinases and TIMPs.

Journal article

Matrix metalloproteinases (MMPs), also called matrixins, function in the extracellular environment of cells and degrade both matrix and non-matrix proteins. They play central roles in morphogenesis, wound healing, tissue repair and remodelling in response to injury, e.g. after myocardial infarction, and in progression of diseases such as atheroma, arthritis, cancer and chronic tissue ulcers. They are multi-domain proteins and their activities are regulated by tissue inhibitors of metalloprote...

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Authors: Nagase, H; Visse, R; Murphy, G

• Publication status: Published
• Journal: Cardiovascular research
• Volume: 69
• Issue: 3
• Pages: 562-573
• Publication date: 2006-02-01
• DOI: 10.1016/j.cardiores.2005.12.002
• EISSN: 1755-3245
• ISSN: 0008-6363
• Language: English
• Keywords: Structure-Activity Relationship; Animals; Cardiovascular Diseases; Matrix Metalloproteinases; Matrix Metalloproteinase Inhibitors; Tissue Inhibitor of Metalloproteinases; Humans; Cardiovascular System; Extracellular Matrix