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The disposition of intramuscular artemether in children with cerebral malaria; a preliminary study.

Abstract:

The disposition of intramuscular artemether (AM) was studied in 26 Kenyan children with cerebral malaria. Antimalarial activity determined by bioassay was compared with total plasma AM plus dihydroartemisinin (DHA) determined by high power liquid chromatography (HPLC). Therapeutic levels were achieved in most subjects (21/26) within 1 h of receiving intramuscular AM (3.2 mg/kg), with close correlation between bioassay and HPLC measurements (r = 0.706). However, there was marked inter-individu...

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Publication status:
Published

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Authors


Murphy, SA More by this author
English, M More by this author
Crawley, J More by this author
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Journal:
Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume:
91
Issue:
3
Pages:
331-334
Publication date:
1997
DOI:
EISSN:
1878-3503
ISSN:
0035-9203
URN:
uuid:1c2c984e-7bcb-40da-bd79-f9e6c84c78b0
Source identifiers:
45612
Local pid:
pubs:45612

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