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Journal article

Exploring the surfaceome of Ewing sarcoma identifies a new and unique therapeutic target

Abstract:

The cell surface proteome of tumors mediates the interface between the transformed cells and the general microenvironment, including interactions with stromal cells in the tumor niche and immune cells such as T cells. In addition, the cell surface proteome of individual cancers defines biomarkers for thattumor type and potential proteins that can be the target of antibody-mediated therapy. We have used next-generation deep RNA sequencing (RNA-seq) coupled to an inhouse database of genes encod...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1073/pnas.1521251113

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More from this funder
Name:
Leukaemia and Lymphoma Research
Grant:
12051
More from this funder
Name:
Wellcome Trust
Grant:
099246/Z/12/Z
More from this funder
Name:
Medical Research Council
Grant:
MR/J000612/1
Publisher:
National Academy of Sciences
Journal:
Proceedings of the National Academy of Sciences More from this journal
Volume:
113
Issue:
13
Pages:
3603-3608
Publication date:
2016-03-01
Acceptance date:
2016-02-17
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Language:
English
Keywords:
Pubs id:
pubs:611286
UUID:
uuid:1c27c829-8850-413f-b090-03346e599efa
Local pid:
pubs:611286
Source identifiers:
611286
Deposit date:
2016-03-30

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