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Journal article

Change in specificity of glycosidase inhibition by N-alkylation of amino sugars.

Abstract:

The synthetic amino sugar 1,4-dideoxy-1,4-imino-L-allitol (DIA) is a moderately good inhibitor of human liver alpha-D-mannosidases and a weak inhibitor of alpha-L-fucosidase, N-acetyl-beta-D-hexosaminidase and beta-D-mannosidase. Methylation of the ring nitrogen of DIA markedly decreases the inhibition of all the glycosidases except N-acetyl-beta-D-hexosaminidase. N-Benzylation of DIA essentially abolishes all inhibitory activity, except towards alpha-L-fucosidase, which is more strongly inhi...

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Publication status:
Published

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Journal:
The Biochemical journal
Volume:
258
Issue:
2
Pages:
613-615
Publication date:
1989-03-05
EISSN:
1470-8728
ISSN:
0264-6021
URN:
uuid:1c26d36b-3e73-4307-b28b-f393b3cdf81f
Source identifiers:
52163
Local pid:
pubs:52163

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