Change in specificity of glycosidase inhibition by N-alkylation of amino sugars.

al Daher, S; Fleet, G; Namgoong, SK; Winchester, B

Abstract:

The synthetic amino sugar 1,4-dideoxy-1,4-imino-L-allitol (DIA) is a moderately good inhibitor of human liver alpha-D-mannosidases and a weak inhibitor of alpha-L-fucosidase, N-acetyl-beta-D-hexosaminidase and beta-D-mannosidase. Methylation of the ring nitrogen of DIA markedly decreases the inhibition of all the glycosidases except N-acetyl-beta-D-hexosaminidase. N-Benzylation of DIA essentially abolishes all inhibitory activity, except towards alpha-L-fucosidase, which is more strongly inhi...

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APA Style

al Daher, S., Fleet, G., Namgoong, S. K., & Winchester, B. (1989). Change in specificity of glycosidase inhibition by N-alkylation of amino sugars. The Biochemical Journal, 258(2), 613–615.

MLA Style

al Daher, S., et al. “Change in Specificity of Glycosidase Inhibition by N-Alkylation of Amino Sugars.” The Biochemical Journal, vol. 258, no. 2, 1989, pp. 613–15.

Chicago Style

Daher, S al, G Fleet, SK Namgoong, and B Winchester. 1989. “Change in Specificity of Glycosidase Inhibition by N-Alkylation of Amino Sugars.” The Biochemical Journal 258 (2): 613–15.
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