Journal article
Change in specificity of glycosidase inhibition by N-alkylation of amino sugars.
- Abstract:
-
The synthetic amino sugar 1,4-dideoxy-1,4-imino-L-allitol (DIA) is a moderately good inhibitor of human liver alpha-D-mannosidases and a weak inhibitor of alpha-L-fucosidase, N-acetyl-beta-D-hexosaminidase and beta-D-mannosidase. Methylation of the ring nitrogen of DIA markedly decreases the inhibition of all the glycosidases except N-acetyl-beta-D-hexosaminidase. N-Benzylation of DIA essentially abolishes all inhibitory activity, except towards alpha-L-fucosidase, which is more strongly inhi...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- Biochemical journal
- Volume:
- 258
- Issue:
- 2
- Pages:
- 613-615
- Publication date:
- 1989-03-01
- EISSN:
-
1470-8728
- ISSN:
-
0264-6021
- Source identifiers:
-
52163
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:52163
- UUID:
-
uuid:1c26d36b-3e73-4307-b28b-f393b3cdf81f
- Local pid:
- pubs:52163
- Deposit date:
- 2012-12-19
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- Copyright date:
- 1989
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