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Mechanics of mouse blastocyst hatching revealed by a hydrogel-based microdeformation assay

Abstract:

Mammalian embryos are surrounded by an acellular shell, the zona pellucida. Hatching out of the zona is crucial for implantation and continued development of the embryo. Clinically, problems in hatching can contribute to failure in assisted reproductive intervention. Although hatching is fundamentally a mechanical process, due to limitations in methodology most studies focus on its biochemical properties. To understand the role of mechanical forces in hatching, we developed a hydrogel deforma...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1073/pnas.1719930115

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Human Genetics Wt Centre
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Human Genetics Wt Centre
ORCID:
0000-0003-3623-600X
Biggins, JS More by this author
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Funding agency for:
Leonavicius, K
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Funding agency for:
Leonavicius, K
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Funding agency for:
Srinivas, S
Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences Journal website
Volume:
115
Issue:
41
Pages:
10375-10380
Publication date:
2018-09-19
Acceptance date:
2018-08-15
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Pubs id:
pubs:920894
URN:
uri:1c1f844a-09ce-49b0-be61-0838b3ff03ce
UUID:
uuid:1c1f844a-09ce-49b0-be61-0838b3ff03ce
Local pid:
pubs:920894

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