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Lack of involvement of the autonomic nervous system in early ventilatory and pulmonary vascular acclimatization to hypoxia in humans.

Abstract:

The activity within the autonomic nervous system may be altered following sustained exposure to hypoxia, and it is possible that this increase in activity underlies the early acclimatization of both ventilation and the pulmonary vasculature to hypoxia. To test this hypothesis, seven individuals were infused with the ganglionic blocker trimetaphan before and after an 8 h exposure to hypoxia. The short half-life of trimetaphan should ensure that the initial infusion does not affect acclimatizat...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Balanos, GM More by this author
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Journal:
The Journal of physiology
Volume:
579
Issue:
Pt 1
Pages:
215-225
Publication date:
2007-02-05
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
URN:
uuid:1c1eb8cf-0a64-49a3-8139-91eb6214242c
Source identifiers:
113925
Local pid:
pubs:113925

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