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Colicins exploit native disorder to gain cell entry: a hitchhiker's guide to translocation.

Abstract:

The translocation of protein toxins into a cell relies on a myriad of protein-protein interactions. One such group of toxins are enzymatic E colicins, protein antibiotics produced by Escherichia coli in times of stress. These proteins subvert ordinary nutrient uptake mechanisms to enter the cell and unleash nuclease activity. We, and others, have previously shown that uptake of ColE9 (colicin E9) is dependent on engagement of the OM (outer membrane) receptors BtuB and OmpF as well as recruitm...

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Publication status:
Published

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Publisher copy:
10.1042/bst0361409

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
Journal:
Biochemical Society transactions More from this journal
Volume:
36
Issue:
Pt 6
Pages:
1409-1413
Publication date:
2008-12-01
DOI:
EISSN:
1470-8752
ISSN:
0300-5127
Language:
English
Keywords:
Pubs id:
pubs:310204
UUID:
uuid:1c07dbbc-6874-48ee-8f1b-af83aabd65c5
Local pid:
pubs:310204
Source identifiers:
310204
Deposit date:
2013-11-16

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