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Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone.

Abstract:

Neoplasms have a striking tendency to metastasize or "home" to bone. Hematopoietic cells also home to bone during embryonic development, where evidence points to the chemokine stromal cell-derived factor-1 (SDF-1 or CXCL12; expressed by osteoblasts and endothelial cells) and its receptor (CXCR4) as key elements in these processes. We hypothesized that metastatic prostate carcinomas also use the SDF-1/CXCR4 pathway to localize to the bone. To test this, levels of CXCR4 expression were determin...

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Journal:
Cancer research
Volume:
62
Issue:
6
Pages:
1832-1837
Publication date:
2002-03-05
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:1c0477ed-f1a8-46ab-98c0-202b64f01caa
Source identifiers:
126388
Local pid:
pubs:126388

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