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A large-scale, consortium-based genomewide association study of asthma.

Abstract:

BACKGROUND: Susceptibility to asthma is influenced by genes and environment; implicated genes may indicate pathways for therapeutic intervention. Genetic risk factors may be useful in identifying subtypes of asthma and determining whether intermediate phenotypes, such as elevation of the total serum IgE level, are causally linked to disease. METHODS: We carried out a genomewide association study by genotyping 10,365 persons with physician-diagnosed asthma and 16,110 unaffected persons, all of...

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Publication status:
Published

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Publisher copy:
10.1056/nejmoa0906312

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Journal:
New England journal of medicine
Volume:
363
Issue:
13
Pages:
1211-1221
Publication date:
2010-09-01
DOI:
EISSN:
1533-4406
ISSN:
0028-4793
Source identifiers:
105195

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