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The human myometrium differentially expresses mTOR signalling components before and during pregnancy: evidence for regulation by progesterone

Abstract:

Emerging studies implicate the signalling of the mammalian target of rapamycin (mTOR) in a number of reproductive functions. To this date, there are no data regarding the expression of mTOR signalling components in the human myometrium during pregnancy. We hypothesized that mTOR-related genes might be differentially expressed in term or preterm labour as well as in labour or non-labour myometria during pregnancy. Using quantitative RT-PCR we demonstrate for first time that there is a signific...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.jsbmb.2013.02.017

Authors


Foster, HA More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Turkcigdem, S More by this author
Goumenou, A More by this author
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Publisher:
Elsevier Ltd. Publisher's website
Journal:
The Journal of steroid biochemistry and molecular biology Journal website
Volume:
139
Pages:
166-172
Publication date:
2013-03-26
Acceptance date:
2013-02-24
DOI:
EISSN:
1879-1220
ISSN:
0960-0760
URN:
uuid:1bfe4c2f-f3bc-4744-ad5e-59f292740198
Source identifiers:
406521
Local pid:
pubs:406521

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