Journal article
Accounting for control mislabeling in case-control biomarker studies.
- Abstract:
-
In biomarker discovery studies, uncertainty associated with case and control labels is often overlooked. By omitting to take into account label uncertainty, model parameters and the predictive risk can become biased, sometimes severely. The most common situation is when the control set contains an unknown number of undiagnosed, or future, cases. This has a marked impact in situations where the model needs to be well-calibrated, e.g., when the prediction performance of a biomarker panel is eva...
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- Publication status:
- Published
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- Publisher copy:
- 10.1021/pr200507b
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Authors
Bibliographic Details
- Journal:
- Journal of proteome research
- Volume:
- 10
- Issue:
- 12
- Pages:
- 5562-5567
- Publication date:
- 2011-12-01
- DOI:
- EISSN:
-
1535-3907
- ISSN:
-
1535-3893
- Source identifiers:
-
193127
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:193127
- UUID:
-
uuid:1be53b22-af6b-4553-a8cc-755c7dc73eae
- Local pid:
- pubs:193127
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2011
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