Delineating the cellular pathways of hematopoietic lineage commitment.

Journal article

The prevailing model for adult hematopoiesis postulates that the first lineage commitment step results in a strict separation of common myeloid and common lymphoid pathways. However, the recent identification of granulocyte/monocyte (GM)-lymphoid restricted lymphoid-primed multipotent progenitors (LMPPs) and primitive common myeloid progenitors (CMPs) within the "HSC" compartment provide compelling support for establishment of independent GM-megakaryocyte/erythroid (GM-MkE) and GM-lymphoid commitment pathways as decisive early lineage fate decisions. These changes in lineage potentials are corroborated by corresponding changes in multilineage transcriptional priming, as LMPPs down-regulate MkE priming but become GM-lymphoid transcriptionally primed, whereas CMPs are GM-MkE primed. These distinct biological and molecular relationships are established already in the fetal liver.

Authors: Luc, S; Buza-Vidas, N; Jacobsen, SE

• Publication status: Published
• Journal: Seminars in immunology
• Volume: 20
• Issue: 4
• Pages: 213-220
• Publication date: 2008-08-01
• DOI: 10.1016/j.smim.2008.07.005
• EISSN: 1096-3618
• ISSN: 1044-5323
• Language: English
• Keywords: Animals; Signal Transduction; Adult Stem Cells; Models, Biological; Humans; Cell Lineage; Fetal Stem Cells; Hematopoietic Stem Cells; Cell Differentiation