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Computational assessment of drug−induced effects on the electrocardiogram: from ion channel block to body surface potentials

Abstract:

Background and purpose This work is based on the computational models describing the physiology of the electrical wave propagation in the heart. The goal is to show the ability of computational models to reproduce the effect drugs on the electrical activity of the heart at the cell, the organ (heart) and the ECG body surface potential levels. Experimental approach We use the state-of–the-art mathematical models governing the heart electrical activity. The ...

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Authors


MO Bernabeu More by this author
P Pathmanathan More by this author
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Journal:
British Journal of Pharmacology
Volume:
168
Issue:
3
Pages:
718-733
Publication date:
2013
DOI:
URN:
uuid:1bd553fc-2276-4881-a372-c5c7b4a54a68
Local pid:
cs:6246

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