Journal article icon

Journal article

Low O6-methylguanine-DNA methyltransferase (MGMT) expression and response to temozolomide in aggressive pituitary tumours.

Abstract:

CONTEXT: Recent case reports detail the successful use of temozolomide in the management of aggressive pituitary tumours. O(6)-methylguanine-DNA methyltransferase (MGMT) is a DNA repair protein that counteracts the effect of temozolomide. OBJECTIVE: To study MGMT expression in pituitary tumours and consider whether MGMT expression is associated with response to temozolomide therapy in aggressive pituitary tumours. PATIENTS: We report two patients with aggressive pituitary tumours treated wit...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


McCormack, AI More by this author
McDonald, KL More by this author
Expand authors...
Journal:
Clinical endocrinology
Volume:
71
Issue:
2
Pages:
226-233
Publication date:
2009-08-05
DOI:
EISSN:
1365-2265
ISSN:
0300-0664
URN:
uuid:1bce8d87-27b8-4d20-ba32-aa3defd5b541
Source identifiers:
138526
Local pid:
pubs:138526

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP